The man's head splitting open in a claymation style.

The ad opens with a man touching his head, looking distressed. The scene transitions to a claymation-style animation of the man, whose head splits open, symbolizing intense pain. He is then shown in a bar, unable to meet a date. The animation continues with him sitting alone on a couch surrounded by cats, looking miserable. The ad then shows a box of Advil, followed by abstract visuals of the pill dissolving and spreading. The final scenes show the man looking relieved and the Advil branding with a call to action.